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[68Ga]Ga-P8
- Development stage
- Preclinical
- Lead developer
- ShanghaiTech University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
[68Ga]Ga-P8 is a novel gallium-68 labeled macrocyclic peptide positron emission tomography (PET) tracer designed to target the urokinase-type plasminogen activator receptor (uPAR), a well-established biomarker for aggressive malignancies. Developed through a dual-optimization strategy involving head-to-tail macrocyclization and linker engineering, [68Ga]Ga-P8 features a peptide-based linker that provides high hydrophilicity, high binding affinity (Kd < 5 nM), and excellent metabolic stability. In preclinical tumor xenograft models, [68Ga]Ga-P8 demonstrated rapid and high tumor accumulation with prolonged retention, significantly outperforming the reference tracer [68Ga]Ga-DOTA-AE105.
- Other names
- 68Ga-P8Ga-P8Ga-P-8Ga-P 8
02
Targets
PLAUR (Urokinase plasminogen activator receptor)
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